Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring

Highlights • Prenatal FLU impaired maturation of the male external genitalia. • Prenatally FLU-exposed rats showed atrophied seminal vesicles. • Prenatal FLU reduced dendritic arborizations of mesencephalic structures. • Prenatal FLU reduced the number of tyrosine hydroxylase-immunopositive neurons...

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Veröffentlicht in:	Neuroscience 2014-10, Vol.278, p.122-135
Hauptverfasser:	Pallarés, M.E, Adrover, E, Imsen, M, González, D, Fabre, B, Mesch, V, Baier, C.J, Antonelli, M.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - administration & dosage Androgens - physiology Animals Body Weight - drug effects Brain - drug effects Brain - growth & development Brain - metabolism Female Flutamide - administration & dosage hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - metabolism Male male rat offspring Neurology Neurons - drug effects Neurons - metabolism Organ Size - drug effects prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - growth & development Prefrontal Cortex - metabolism Pregnancy prenatal flutamide Rats Rats, Wistar Stress, Physiological Testosterone - blood Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase ventral tegmental area Ventral Tegmental Area - drug effects Ventral Tegmental Area - growth & development Ventral Tegmental Area - metabolism
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Zusammenfassung:	Highlights • Prenatal FLU impaired maturation of the male external genitalia. • Prenatally FLU-exposed rats showed atrophied seminal vesicles. • Prenatal FLU reduced dendritic arborizations of mesencephalic structures. • Prenatal FLU reduced the number of tyrosine hydroxylase-immunopositive neurons in the VTA of prepubertal rats. • Results resemble organizational effects of prenatal stress on male offspring.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.07.074