Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance

Highlights • Blood–brain barrier changes in epileptogenic brain tissue. • Role of BBB in the development and progression of epilepsy. • Role of BBB in the development of drug resistance. • Potential new therapies that may restore normal BBB function.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-09, Vol.277, p.455-473
Hauptverfasser:	van Vliet, E.A, Aronica, E, Gorter, J.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiopathology blood–brain barrier Brain - drug effects Brain - physiopathology brain inflammation Drug Resistance Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - physiopathology epileptogenesis Humans multidrug transporter Neuroimmunomodulation - drug effects Neuroimmunomodulation - physiology Neurology pharmacoresistance temporal lobe epilepsy
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Beschreibung
Zusammenfassung:	Highlights • Blood–brain barrier changes in epileptogenic brain tissue. • Role of BBB in the development and progression of epilepsy. • Role of BBB in the development of drug resistance. • Potential new therapies that may restore normal BBB function.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.07.030