Downstream effects of striatal-enriched protein tyrosine phosphatase reduction on RNA expression in vivo and in vitro

Highlights • Microarray data from STEP KO mice-identified pathways related to ERK signaling, neurodevelopment, and synaptic plasticity. • STEP KO induced expression of immediate-early genes which were validated in the striatum, cortex and hippocampus by RT-PCR. • Primary cortical neurons treated wit...

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Veröffentlicht in:	Neuroscience 2014-10, Vol.278, p.62-69
Hauptverfasser:	Reinhart, V.L, Nguyen, T, Gerwien, R, Kuhn, M, Yates, P.D, Lanz, T.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corpus Striatum - metabolism Gene Expression HEK293 Cells Hippocampus - metabolism Humans Lentivirus Male MAP Kinase Signaling System Mice Mice, Knockout microarray Nerve Growth Factors - genetics Neurology Neurons - metabolism NMDA Protein Tyrosine Phosphatases - genetics PTPN5 qRT-PCR Rats RNA - metabolism schizophrenia Signal Transduction STEP
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Beschreibung
Zusammenfassung:	Highlights • Microarray data from STEP KO mice-identified pathways related to ERK signaling, neurodevelopment, and synaptic plasticity. • STEP KO induced expression of immediate-early genes which were validated in the striatum, cortex and hippocampus by RT-PCR. • Primary cortical neurons treated with STEP shRNA showed elevated DUSP4, FOS, SPP1, and STXBP1 mRNA. • Primary cortical neurons treated with STEP shRNA showed reduced CAMK2A, SEPT11 and TMEM114 mRNA.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.002