Tegaserod, a small compound mimetic of polysialic acid, promotes functional recovery after spinal cord injury in mice

Highlights • Tegaserod improves motor recovery after spinal cord injury in mice. • Surviving neuron numbers are higher after injury in tegaserod-treated mice. • Tegaserod treatment reduces glial scar formation after spinal cord injury. • Tegaserod treatment enhances monoaminergic axon regrowth after...

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Veröffentlicht in:	Neuroscience 2014-09, Vol.277, p.356-366
Hauptverfasser:	Pan, H.-C, Shen, Y.-Q, Loers, G, Jakovcevski, I, Schachner, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - pathology Astrocytes - physiology axonal regeneration Axons - drug effects Axons - pathology Axons - physiology Cell Count Cell Survival - drug effects Cicatrix - drug therapy Cicatrix - pathology Cicatrix - physiopathology Disease Models, Animal Female Glial Fibrillary Acidic Protein Gliosis - drug therapy Gliosis - pathology Gliosis - physiopathology Hindlimb - physiopathology Indoles - pharmacology Mice, Inbred C57BL Motor Activity - drug effects Motor Activity - physiology motor function Nerve Tissue Proteins - metabolism Neurology Neurons - drug effects Neurons - pathology Neurons - physiology Neuroprotective Agents - pharmacology polysialic acid Recovery of Function - drug effects Recovery of Function - physiology Serotonin - metabolism Spinal Cord - drug effects Spinal Cord - pathology Spinal Cord - physiopathology Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology spinal cord injury tegaserod Tyrosine 3-Monooxygenase - metabolism
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Zusammenfassung:	Highlights • Tegaserod improves motor recovery after spinal cord injury in mice. • Surviving neuron numbers are higher after injury in tegaserod-treated mice. • Tegaserod treatment reduces glial scar formation after spinal cord injury. • Tegaserod treatment enhances monoaminergic axon regrowth after spinal cord injury.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.06.069