Neuropeptide Y attenuates anxiety- and depression-like effects of cholecystokinin-4 in mice

Highlights • Cholecystokinin-4 (CCK-4) induces anxiety- and depression-like effects in mice. • Neuropeptide Y (NPY) produces anxiolytic and antidepressant effects in mice. • NPY attenuates CCK-4 induced anxiety- and depression-like symptoms. • CCK-4 administration decreases NPY expression in the lim...

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Veröffentlicht in:	Neuroscience 2014-09, Vol.277, p.818-830
Hauptverfasser:	Desai, S.J, Borkar, C.D, Nakhate, K.T, Subhedar, N.K, Kokare, D.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology anxiety Anxiety - drug therapy Anxiety - physiopathology Arginine - analogs & derivatives Arginine - pharmacology Brain - drug effects Brain - physiopathology cholecystokinin depression Depression - drug therapy Depression - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Immunohistochemistry Male Mice Motor Activity - drug effects Motor Activity - physiology Neurology neuropeptide Y Neuropeptide Y - administration & dosage Neuropeptide Y - metabolism Neuropsychological Tests Psychotropic Drugs - administration & dosage Receptors, Neuropeptide Y - agonists Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - metabolism Social Behavior Swimming Tetragastrin - administration & dosage Tetragastrin - metabolism
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Zusammenfassung:	Highlights • Cholecystokinin-4 (CCK-4) induces anxiety- and depression-like effects in mice. • Neuropeptide Y (NPY) produces anxiolytic and antidepressant effects in mice. • NPY attenuates CCK-4 induced anxiety- and depression-like symptoms. • CCK-4 administration decreases NPY expression in the limbic brain areas.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.07.062