Increased Plasma Incretin Concentrations Identifies a Subset of Patients with Persistent Congenital Hyperinsulinism without KATP  Channel Gene Defects

Increased Plasma Incretin Concentrations Identifies a Subset of Patients with Persistent Congenital Hyperinsulinism without KATP  Channel Gene Defects

Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify thes...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of pediatrics 2015, Vol.166 (1), p.191-194
Hauptverfasser: Shi, Yanqin, PhD, Avatapalle, Hima B., MBChB, Skae, Mars S., MBChB, MPhil, Padidela, Raja, MD, Newbould, Melanie, FRCPath, Rigby, Lindsey, BSc, RGN, RSCN, Flanagan, Sarah E., PhD, Ellard, Sian, PhD, FRCPath, Rahier, Jacques, MD, PhD, Clayton, Peter E., MBChB, MD, Dunne, Mark J., PhD, Banerjee, Indraneel, MD, Cosgrove, Karen E., PhD
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers - blood
Child, Preschool
Congenital Hyperinsulinism - blood
Congenital Hyperinsulinism - genetics
Humans
Incretins - blood
Infant
Infant, Newborn
KATP Channels - genetics
Mutation
Pediatrics
United Kingdom
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2014.09.019