Cryopreservation of testicular tissue in children

The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubert...

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Veröffentlicht in:	Bulletin de l'Académie nationale de médecine 2013-04, Vol.197 (4-5), p.877-86; discussion 886
Hauptverfasser:	Rives, Nathalie, Milazzo, Jean-Pierre, Travers, Albanne, Arkoun, Brahim, Bironneau, Amandine, Sibert, Louis, Liard-Zmuda, Agnès, Marie-Cardine, Aude, Schneider, Pascale, Vannier, Jean-Pierre, Macé, Bertrand
Format:	Artikel
Sprache:	fre
Schlagworte:	Adolescent Animals Antineoplastic Agents - adverse effects Child Child, Preschool Cryopreservation - methods Fertility Preservation - methods Humans Infant Infertility, Male - etiology Infertility, Male - prevention & control Male Neoplasms - therapy Radiotherapy - adverse effects Replantation Seminiferous Tubules Spermatogonia Testis - drug effects Testis - radiation effects Testis - surgery Transplantation, Autologous Transplantation, Heterotopic
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Beschreibung
Zusammenfassung:	The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.
ISSN:	0001-4079
DOI:	10.1016/S0001-4079(19)31531-6