Cytokeratin 19 expression in primary thoracic tumors and lymph node metastases

Highlights • We performed a large-scale analysis of the CK19 expression in thoracic tumors. • Thoracic tumors except for PCs, CTs, and SCCs were positive for CK19. • We showed the possibility of OSNA method in thoracic tumors. • Inflammatory cells showed weak CK19 staining in primary sites and LNs....

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2014-12, Vol.86 (3), p.318-323
Hauptverfasser:	Masai, Kyohei, Nakagawa, Kazuo, Yoshida, Akihiko, Sakurai, Hiroyuki, Watanabe, Shun-ichi, Asamura, Hisao, Tsuta, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Breast Neoplasms - genetics Breast Neoplasms - pathology CK19 Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Intraoperative Period Keratin-19 - biosynthesis Keratin-19 - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lung Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology Medical sciences Nucleic Acid Amplification Techniques OSNA Pneumology Pulmonary/Respiratory Thoracic Neoplasms - classification Thoracic Neoplasms - genetics Thoracic Neoplasms - pathology TMA Tumors of the respiratory system and mediastinum
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Zusammenfassung:	Highlights • We performed a large-scale analysis of the CK19 expression in thoracic tumors. • Thoracic tumors except for PCs, CTs, and SCCs were positive for CK19. • We showed the possibility of OSNA method in thoracic tumors. • Inflammatory cells showed weak CK19 staining in primary sites and LNs.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2014.09.018