Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis

Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis

We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eota...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2014-12, Vol.158 (2), p.192-196
Hauptverfasser: Zhebrun, D. A., Totolyan, Areg A., Maslyanskii, A. L., Titov, A. G., Patrukhin, A. P., Kostareva, A. A., Gol’tseva, I. S.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Arthritis
Arthritis, Rheumatoid - metabolism
B cells
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chemokines, CC - biosynthesis
Chemokines, CC - metabolism
Development and progression
Female
Humans
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Nephelometry and Turbidimetry
Osteoarthritis - metabolism
Pathology
Receptors, CCR - biosynthesis
Receptors, CCR - metabolism
Rheumatoid factor
RNA
RNA, Messenger - metabolism
Statistics, Nonparametric
Synovial Membrane - metabolism
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Zusammenfassung:We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2720-9