Fluoride alters connexin expression in rat incisor pulp

Fluoride alters connexin expression in rat incisor pulp

Highlights • Chronic NaF exposure alters the expression pattern of connexins in dental pulp. • Increased Cx43 expression and ALP activity were related to fluorotic lesion. • Changes triggered by NaF may have a stimulating effect on dentin mineralization. • NaF decreases incisor diameter reflecting a...

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Veröffentlicht in:Archives of oral biology 2015-02, Vol.60 (2), p.313-319
Hauptverfasser: Centeno, V.A, Fontanetti, P.A, Interlandi, V, Ponce, R.H, Gallará, R.V
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Alkaline Phosphatase - metabolism
Animals
Connexins
Connexins - genetics
Connexins - metabolism
Dental Pulp - drug effects
Dental Pulp - metabolism
Dental pulp tissue
Dentistry
Gene Expression
Incisor
Male
Rat dental fluorosis
Rats
Rats, Wistar
Real-Time Polymerase Chain Reaction
Sodium fluoride
Sodium Fluoride - pharmacology
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Beschreibung
Zusammenfassung:Highlights • Chronic NaF exposure alters the expression pattern of connexins in dental pulp. • Increased Cx43 expression and ALP activity were related to fluorotic lesion. • Changes triggered by NaF may have a stimulating effect on dentin mineralization. • NaF decreases incisor diameter reflecting an alteration in the growth process. • None of the mandibular growth parameters were affected by NaF treatment.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2014.11.003