The association between uncarboxylated matrix Gla protein and lipoprotein-associated phospholipase A2

Highlights • Lipoprotein-associated phospholipase A2 activity (aLp-PLA2) was associated with desphospho-uncarboxylated matrix Gla protein (dp-ucMGP). • The patients in the top quartile of dp-ucMGP had three-fold increase of all-cause mortality, but no effect of high Lp-PLA2 activity was found. • No interaction of dp-ucMGP and aLp-PLA2 in terms of mortality risk was found. • We may speculate, that pathophysiology of aLp-PLA2 involves also vascular calcification. • Increased dp-ucMGP should be more appropriate biomarker of residual mortality risk than increased Lp-PLA2 activity.