The critical role of O2 provision in the dynamic adjustment of oxidative phosphorylation

The critical role of O2 provision in the dynamic adjustment of oxidative phosphorylation

It has been proposed that the adjustment of oxygen uptake (V˙O2) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O2 delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O2 provision to t...

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Veröffentlicht in:Exercise and sport sciences reviews 2014-01, Vol.42 (1), p.4-11
Hauptverfasser: Murias, Juan M, Spencer, Matthew D, Paterson, Donald H
Format: Artikel
Sprache:eng
Schlagworte:
Exercise - physiology
Humans
Oxidative Phosphorylation
Oxygen - physiology
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Zusammenfassung:It has been proposed that the adjustment of oxygen uptake (V˙O2) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O2 delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O2 provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals.
ISSN:0091-6331
1538-3008
DOI:10.1249/jes.0000000000000005