Interleukin-1 β sensitizes the response of the gastric vagal afferent to cholecystokinin in rat

Interleukin-1 β (IL-1 β) and cholecystokinin (CCK) are important mediators in the development of anorexic response during disease. The role of IL-1 β and CCK in the peripheral mechanisms of anorexia was studied by recording the mass afferent activity of the gastric vagal nerve in anesthetized rats....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 1997-06, Vol.229 (1), p.33-36
Hauptverfasser:	Bucinskaite, Violeta, Kurosawa, Mieko, Miyasaka, Kyoko, Funakoshi, Akihiro, Lundeberg, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cholecystokinin Fundamental and applied biological sciences. Psychology Interleukin-1 Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rat Type A cholecystokinin receptor Vagal afferent nerve Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Interleukin-1 β (IL-1 β) and cholecystokinin (CCK) are important mediators in the development of anorexic response during disease. The role of IL-1 β and CCK in the peripheral mechanisms of anorexia was studied by recording the mass afferent activity of the gastric vagal nerve in anesthetized rats. The i.v. administration of CCK (1 nmol) increased the activity of the vagal nerve, and this response was raised by 55–72% 2 h after i.v. injection of IL-1 β. It is proposed that IL-1 β-induced anorexia is mediated via the sensitization of type A CCK receptors in the periphery.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/S0304-3940(97)00406-0