Rare occurrence of EGFRvIII deletion in head and neck squamous cell carcinoma

Highlights • Out of 638 samples analyzed, only 2 samples were positive for EGFRvIII deletion. • EGFRvIII deletion is very rare in head and neck squamous cell carcinoma (HNSCC). • EGFRvIII deletion should not be included in regular diagnostic tests for HNSCC.

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Bibliographische Detailangaben
Veröffentlicht in:	Oral oncology 2015-01, Vol.51 (1), p.53-58
Hauptverfasser:	Khattri, Arun, Zuo, Zhixiang, Brägelmann, Johannes, Keck, Michaela K, El Dinali, Mohamed, Brown, Christopher D, Stricker, Thomas, Munagala, Anish, Cohen, Ezra E.W, Lingen, Mark W, White, Kevin P, Vokes, Everett E, Seiwert, Tanguy Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Base Sequence Carcinoma, Squamous Cell - genetics DNA Primers Epidermal growth factor receptor Epidermal growth factor variant III Female Gene Deletion Head and Neck Neoplasms - genetics Head and neck squamous cell carcinoma Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Otolaryngology Receptor, Epidermal Growth Factor - genetics Sequence Analysis, RNA
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Beschreibung
Zusammenfassung:	Highlights • Out of 638 samples analyzed, only 2 samples were positive for EGFRvIII deletion. • EGFRvIII deletion is very rare in head and neck squamous cell carcinoma (HNSCC). • EGFRvIII deletion should not be included in regular diagnostic tests for HNSCC.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2014.08.014