Assessment of Regional Gray Matter Loss in Dementia with Lewy Bodies: A Surface-Based MRI Analysis

Objective To compare magnetic resonance imaging (MRI) patterns of cortical thinning in subjects with dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and normal aging and investigate the relationship between cortical thickness and clinical measures. Methods Study participants (31 DLB,...

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Veröffentlicht in:	The American journal of geriatric psychiatry 2015, Vol.23 (1), p.38-46
Hauptverfasser:	Watson, Rosie, Ph.D, Colloby, Sean J., Ph.D, Blamire, Andrew M., Ph.D, O’Brien, John T., D.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - pathology Alzheimer Disease - pathology Alzheimer disease's Cerebral Cortex - pathology Dementia Female Humans Internal Medicine Lewy body disease Lewy Body Disease - pathology Magnetic Resonance Imaging - methods Male MRI neuroimaging
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Zusammenfassung:	Objective To compare magnetic resonance imaging (MRI) patterns of cortical thinning in subjects with dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and normal aging and investigate the relationship between cortical thickness and clinical measures. Methods Study participants (31 DLB, 30 AD, and 33 healthy comparison subjects) underwent 3-Tesla T1 -weighted MRI and completed clinical and cognitive assessments. We used the FreeSurfer analysis package to measure cortical thickness and investigated the patterns of cortical thinning across groups. Results Cortical thinning in AD was found predominantly in the temporal and parietal areas extending into the frontal lobes (N = 63, df = 59, t >3.3, p 3.6, p 2.8, p
ISSN:	1064-7481 1545-7214
DOI:	10.1016/j.jagp.2014.07.005