MICROBIAL TRANSFORMATION OF IMMUNOSUPPRESSIVE COMPOUNDS: II. SPECIFIC DESMETHYLATION OF 13-METHOXY GROUP OF FK 506 AND FR 900520 BY Actinomycete sp. ATCC 53828

FK 506 and FR 900520 are a new class of fermentation products, isolated from Streptomyces tsukubaensis/Streptomyces hygroscopicus species ascomyceticus MA6475, showing potent inhibition of T cell activation. In the course of our recent investigations on microbial modification of FK 506/FR 900520, se...

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Veröffentlicht in:	Journal of antibiotics 1992/04/25, Vol.45(4), pp.577-580
Hauptverfasser:	CHEN, TOM S., ARISON, BYRON H., WICKER, LINDA S., INAMINE, EDWARD S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Immunomodulators Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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