MICROBIAL TRANSFORMATION OF IMMUNOSUPPRESSIVE COMPOUNDS: II. SPECIFIC DESMETHYLATION OF 13-METHOXY GROUP OF FK 506 AND FR 900520 BY Actinomycete sp. ATCC 53828

MICROBIAL TRANSFORMATION OF IMMUNOSUPPRESSIVE COMPOUNDS: II. SPECIFIC DESMETHYLATION OF 13-METHOXY GROUP OF FK 506 AND FR 900520 BY Actinomycete sp. ATCC 53828

FK 506 and FR 900520 are a new class of fermentation products, isolated from Streptomyces tsukubaensis/Streptomyces hygroscopicus species ascomyceticus MA6475, showing potent inhibition of T cell activation. In the course of our recent investigations on microbial modification of FK 506/FR 900520, se...

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Veröffentlicht in:Journal of antibiotics 1992/04/25, Vol.45(4), pp.577-580
Hauptverfasser: CHEN, TOM S., ARISON, BYRON H., WICKER, LINDA S., INAMINE, EDWARD S.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Immunomodulators
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:FK 506 and FR 900520 are a new class of fermentation products, isolated from Streptomyces tsukubaensis/Streptomyces hygroscopicus species ascomyceticus MA6475, showing potent inhibition of T cell activation. In the course of our recent investigations on microbial modification of FK 506/FR 900520, several species of actinomycetes were found capable of transforming these drugs. The present report describes the specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by actinomycete sp. ATCC No. 53828.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.577