Antivenom and biological effects of ar-turmerone isolated from Curcuma longa (Zingiberaceae)

A potent antivenom against snakebite was isolated from Curcuma longa, a plant commonly used in traditional Brazilian medicine. The fraction consisting of ar-turmerone neutralized both the hemorrhagic activity present in Bothrops jararaca venom, and the lethal effect of Crotalus durissus terrificus v...

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Veröffentlicht in:	Toxicon (Oxford) 1992-10, Vol.30 (10), p.1211-1218
Hauptverfasser:	Ferreira, Luiza A.F., Henriques, Olga B., Andreoni, Amelia A.S., Vital, Glaucio R.F., Campos, Marcia M.C., Habermehl, Gerhard G., de Moraes, Vera L.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antidotes aromatic compounds Biological and medical sciences Bothrops jararaca Brazil Cell Survival - drug effects Crotalid Venoms - antagonists & inhibitors Crotalid Venoms - toxicity Crotalus Crotalus durissus Curcuma longa General pharmacology hemorrhage Hemorrhage - chemically induced Hemorrhage - pathology Hemorrhage - prevention & control Humans immunosuppression In Vitro Techniques inhibition Ketones - chemistry Ketones - pharmacology Killer Cells, Natural - drug effects Lethal Dose 50 Lymphocytes - drug effects Magnetic Resonance Spectroscopy Medical sciences medicinal properties Mice natural killer cells neurotoxins Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Plants, Medicinal - chemistry Sesquiterpenes Snake Venoms - antagonists & inhibitors Snake Venoms - toxicity Toluene - analogs & derivatives Toluene - chemistry Toluene - pharmacology toxicity Tropical medicine venoms Viperidae
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Beschreibung
Zusammenfassung:	A potent antivenom against snakebite was isolated from Curcuma longa, a plant commonly used in traditional Brazilian medicine. The fraction consisting of ar-turmerone neutralized both the hemorrhagic activity present in Bothrops jararaca venom, and the lethal effect of Crotalus durissus terrificus venom in mice. Immunological studies demonstrated that this fraction also inhibited the proliferation and the natural killer activity of human lymphocytes.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/0041-0101(92)90437-A