An eco-friendly and water mediated product selective synthesis of 2-aminopyrimidines and their in vitro anti-bacterial evaluation

An efficient, eco-friendly product selective synthesis of a library of 2-amino-6-styryl pyrimidines/dihydro analogues and their in vitro anti-bacterial activity has been achieved. [Display omitted] A greener water mediated protocol for the efficient synthesis of a library of 2-amino-6-styryl pyrimidines (4) and their dihydro analogues (3) has been reported. Most of the saturated compounds (3) rather than their unsaturated analogues (4) showed better anti-bacterial (in vitro) activity against three human pathogens viz. Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli. In particular, three of them (3b, 3i &3k) exhibited high inhibition against the growth of all the three pathogens comparable with that of the reference drug, tetracycline.