Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system

Highlights • CSD enhanced lipid peroxidation in cortex, meninges and trigeminal ganglia. • H2 O2 enhanced spiking of trigeminal nerves and promoted CGRP release. • Effect of H2 O2 on spiking was abolished by the TRPA1 antagonist. • Oxidative stress could couple CSD with activation of the trigeminova...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.253, p.341-349
Hauptverfasser:	Shatillo, A, Koroleva, K, Giniatullina, R, Naumenko, N, Slastnikova, A.A, Aliev, R.R, Bart, G, Atalay, M, Gu, C, Khazipov, R, Davletov, B, Grohn, O, Giniatullin, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Calcitonin Gene-Related Peptide - metabolism Cerebral Cortex - blood supply Cerebral Cortex - physiology CGRP Cortical Spreading Depression - drug effects Cortical Spreading Depression - physiology CSD Electric Stimulation Hydrogen Peroxide - metabolism Image Processing, Computer-Assisted Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Magnetic Resonance Imaging Meninges - metabolism migraine Neurology Oxidative Stress - physiology Oxygen - blood Potassium Chloride - pharmacology Rats Rats, Wistar Reactive Oxygen Species - metabolism ROS Thiobarbituric Acid Reactive Substances - metabolism trigeminal ganglion Trigeminal Ganglion - metabolism trigeminal neurons
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Zusammenfassung:	Highlights • CSD enhanced lipid peroxidation in cortex, meninges and trigeminal ganglia. • H2 O2 enhanced spiking of trigeminal nerves and promoted CGRP release. • Effect of H2 O2 on spiking was abolished by the TRPA1 antagonist. • Oxidative stress could couple CSD with activation of the trigeminovascular system.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.002