Modulation of haloperidol-induced catalepsy in rats by GABAergic neural substrate in the inferior colliculus

Highlights • A modulation of the inferior colliculus in the catalepsy induced by haloperidol is proposed. • Haloperidol-induced catalepsy is influenced by midazolam or bicuculline into the inferior colliculus. • The inferior colliculus may play a role in sensorimotor gating and GABAergic mechanisms...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.255, p.212-218
Hauptverfasser:	Tostes, J.G, Medeiros, P, Melo-Thomas, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bicuculline Biological and medical sciences catalepsy Catalepsy - chemically induced Catalepsy - metabolism Dopamine Antagonists - pharmacology Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Fundamental and applied biological sciences. Psychology GABA GABA-A Receptor Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism haloperidol Haloperidol - pharmacology Inferior Colliculi - drug effects Inferior Colliculi - metabolism inferior colliculus Male Medical sciences midazolam Neurology Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • A modulation of the inferior colliculus in the catalepsy induced by haloperidol is proposed. • Haloperidol-induced catalepsy is influenced by midazolam or bicuculline into the inferior colliculus. • The inferior colliculus may play a role in sensorimotor gating and GABAergic mechanisms are involved.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.064