Sleep-wake and diurnal modulation of nitric oxide in the perifornical-lateral hypothalamic area: Real-time detection in freely behaving rats

Highlights • The perifornical-lateral hypothalamic area (PF-LHA) is a wake-promoting region. • Nitric oxide (NO), an endogenous sleep factor, was measured in real-time in the PF-LHA. • In the PF-LHA, NO levels exhibited a waking > REM > nonREM sleep pattern. • NO levels were higher during dark...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.275-284
Hauptverfasser:	Kostin, A, McGinty, D, Szymusiak, R, Alam, M.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Circadian Rhythm - physiology Computer Systems Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Electrodes, Implanted Fundamental and applied biological sciences. Psychology Hypothalamic Area, Lateral - metabolism Male Medical sciences Nafion®-modified Platinum electrode Nervous system (semeiology, syndromes) Neurology nitric oxide Nitric Oxide - metabolism NO sensor perifornical-lateral hypothalamus Rats Rats, Sprague-Dawley sleep deprivation Sleep Stages - physiology sleep-wakefulness Sleep. Vigilance Vertebrates: nervous system and sense organs Wakefulness - physiology
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Zusammenfassung:	Highlights • The perifornical-lateral hypothalamic area (PF-LHA) is a wake-promoting region. • Nitric oxide (NO), an endogenous sleep factor, was measured in real-time in the PF-LHA. • In the PF-LHA, NO levels exhibited a waking > REM > nonREM sleep pattern. • NO levels were higher during dark phase and increased during sleep deprivation. • Nitrergic system in the PF-LHA may play a role in sleep-wake regulation.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.022