Dose-dependent effects of d -methionine for rescuing noise-induced permanent threshold shift in guinea-pigs

Highlights • The study investigating the effects of d -met for rescuing NIHL in guinea-pigs. • The rescue of noise-induced PTS with d -met being in a dose-dependent manner. • d -Met-dose-dependent preservation of ATPase activities in noise-exposed animals. • d -Met mediating a dose-dependent decreas...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.222-229
Hauptverfasser:	Lo, W.-C, Liao, L.-J, Wang, C.-T, Young, Y.-H, Chang, Y.-L, Cheng, P.-W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATPase auditory brainstem response Auditory Threshold - drug effects Auditory Threshold - physiology Biological and medical sciences d-methionine Dose-Response Relationship, Drug Evoked Potentials, Auditory, Brain Stem - drug effects Evoked Potentials, Auditory, Brain Stem - physiology Fundamental and applied biological sciences. Psychology Guinea Pigs lipid peroxidation Methionine - pharmacology Neurology nitric oxide Noise - adverse effects permanent threshold shift Random Allocation Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • The study investigating the effects of d -met for rescuing NIHL in guinea-pigs. • The rescue of noise-induced PTS with d -met being in a dose-dependent manner. • d -Met-dose-dependent preservation of ATPase activities in noise-exposed animals. • d -Met mediating a dose-dependent decrease in noise-induced oxidative stress. • Reversal of oxidative stress and ATPase activities relating to hearing improvement.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.027