Chloride channel 4 is required for nerve growth factor-induced TrkA signaling and neurite outgrowth in PC12 cells and cortical neurons

Highlights • CLC-4 siRNA inhibits the NGF-induced Cl− conductance in PC12 cells. • CLC-4 siRNA inhibits the NGF-induced TrkA, Akt, and moesin activation. • CLC-4 siRNA inhibits the NGF-induced neurite outgrowth in PC12 cells. • CLC-4 siRNA inhibits the neurite outgrowth of cortical neurons....

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Veröffentlicht in:	Neuroscience 2013-12, Vol.253, p.389-397
Hauptverfasser:	Hur, J, Jeong, H.J, Park, J, Jeon, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Cerebral Cortex - cytology Chloride Channels - genetics Chloride Channels - metabolism CLC-4 Dose-Response Relationship, Drug Drug Interactions Embryo, Mammalian Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Membrane Potentials - drug effects Membrane Potentials - physiology Nerve Growth Factor - pharmacology neurite outgrowth Neurites - drug effects Neurites - physiology Neurology neurons Neurons - cytology NGF PC12 Cells Potassium Channel Blockers - pharmacology Rats Receptor, trkA - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tetraethylammonium - pharmacology Time Factors TrkA receptor Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • CLC-4 siRNA inhibits the NGF-induced Cl− conductance in PC12 cells. • CLC-4 siRNA inhibits the NGF-induced TrkA, Akt, and moesin activation. • CLC-4 siRNA inhibits the NGF-induced neurite outgrowth in PC12 cells. • CLC-4 siRNA inhibits the neurite outgrowth of cortical neurons.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.003