Dystonia-associated protein torsinA is not detectable at the nerve terminals of central neurons
Highlights • Immunocytochemistry was used to detect torsinA in presynaptic structures. • Neurons from the striatum, cerebral motor cortex and hippocampus were assessed. • ΔE-torsinA knock-in mice and wild-type littermates were studied. • TorsinA was not detected in presynaptic nerve terminals or axo...
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| Veröffentlicht in: | Neuroscience 2013-12, Vol.253, p.316-329 |
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| creator | Koh, J.-Y Iwabuchi, S Harata, N.C |
| description | Highlights • Immunocytochemistry was used to detect torsinA in presynaptic structures. • Neurons from the striatum, cerebral motor cortex and hippocampus were assessed. • ΔE-torsinA knock-in mice and wild-type littermates were studied. • TorsinA was not detected in presynaptic nerve terminals or axonal shafts. • This morphological study narrows down the possible actions of torsinA. |
| doi_str_mv | 10.1016/j.neuroscience.2013.08.060 |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-4093c187e24ede2c39e12cdd1aa956e7ae7f65253e7dab6f6632b65fdc5f48d43</citedby><cites>FETCH-LOGICAL-c498t-4093c187e24ede2c39e12cdd1aa956e7ae7f65253e7dab6f6632b65fdc5f48d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2013.08.060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28010085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24025868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, J.-Y</creatorcontrib><creatorcontrib>Iwabuchi, S</creatorcontrib><creatorcontrib>Harata, N.C</creatorcontrib><title>Dystonia-associated protein torsinA is not detectable at the nerve terminals of central neurons</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • Immunocytochemistry was used to detect torsinA in presynaptic structures. • Neurons from the striatum, cerebral motor cortex and hippocampus were assessed. • ΔE-torsinA knock-in mice and wild-type littermates were studied. • TorsinA was not detected in presynaptic nerve terminals or axonal shafts. • This morphological study narrows down the possible actions of torsinA.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cadmium Chloride - pharmacology</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cells, Cultured</subject><subject>central neurons</subject><subject>confocal and widefield fluorescence microscopy</subject><subject>Dose-Response Relationship, Drug</subject><subject>dystonia</subject><subject>Embryo, Mammalian</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. 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| subjects | Analysis of Variance Animals Biological and medical sciences Cadmium Chloride - pharmacology Calcium Channel Blockers - pharmacology Cells, Cultured central neurons confocal and widefield fluorescence microscopy Dose-Response Relationship, Drug dystonia Embryo, Mammalian Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Hippocampus - cytology immunocytochemistry Mice Mice, Inbred BALB C Molecular Chaperones - metabolism Nerve Endings - metabolism nerve terminals Neurology Neurons - cytology Neurons - drug effects omega-Agatoxin IVA - pharmacology omega-Conotoxin GVIA - pharmacology Potassium - pharmacology torsinA Vertebrates: nervous system and sense organs |
| title | Dystonia-associated protein torsinA is not detectable at the nerve terminals of central neurons |
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