Dystonia-associated protein torsinA is not detectable at the nerve terminals of central neurons

Highlights • Immunocytochemistry was used to detect torsinA in presynaptic structures. • Neurons from the striatum, cerebral motor cortex and hippocampus were assessed. • ΔE-torsinA knock-in mice and wild-type littermates were studied. • TorsinA was not detected in presynaptic nerve terminals or axo...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.253, p.316-329
Hauptverfasser:	Koh, J.-Y, Iwabuchi, S, Harata, N.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Cadmium Chloride - pharmacology Calcium Channel Blockers - pharmacology Cells, Cultured central neurons confocal and widefield fluorescence microscopy Dose-Response Relationship, Drug dystonia Embryo, Mammalian Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Hippocampus - cytology immunocytochemistry Mice Mice, Inbred BALB C Molecular Chaperones - metabolism Nerve Endings - metabolism nerve terminals Neurology Neurons - cytology Neurons - drug effects omega-Agatoxin IVA - pharmacology omega-Conotoxin GVIA - pharmacology Potassium - pharmacology torsinA Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Immunocytochemistry was used to detect torsinA in presynaptic structures. • Neurons from the striatum, cerebral motor cortex and hippocampus were assessed. • ΔE-torsinA knock-in mice and wild-type littermates were studied. • TorsinA was not detected in presynaptic nerve terminals or axonal shafts. • This morphological study narrows down the possible actions of torsinA.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.08.060