Effects of mild TBI from repeated blast overpressure on the expression and extinction of conditioned fear in rats

Highlights • In rats, we evaluated the impact of mild TBI on conditioned fear. • Conditioned fear was implemented using a conditioned suppression procedure. • Mild TBI was produced through multiple blast overpressure exposures. • Mild TBI blunted the expression of a conditioned fear while not delayi...

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Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.120-129
Hauptverfasser:	Genovese, R.F, Simmons, L.P, Ahlers, S.T, Maudlin-Jeronimo, E, Dave, J.R, Boutte, A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blast Injuries - physiopathology Blast Injuries - psychology blast overpressure Brain Injuries - physiopathology Brain Injuries - psychology conditioned fear Conditioning, Operant - physiology Fear - physiology Fear - psychology Fundamental and applied biological sciences. Psychology Male mTBI Neurology operant conditioning PTSD Rats Rats, Sprague-Dawley Reinforcement Schedule stress processes Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • In rats, we evaluated the impact of mild TBI on conditioned fear. • Conditioned fear was implemented using a conditioned suppression procedure. • Mild TBI was produced through multiple blast overpressure exposures. • Mild TBI blunted the expression of a conditioned fear while not delaying extinction. • Results are relevant to a possible relationship between mTBI and PTSD.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.021