Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
Highlights • This is the largest study to examine the association between leukocyte DNA methylation and pancreatic cancer. • We found a significant association between Line-1 hypermethylation and risk of pancreatic cancer. • The association was largely unmodified by lifestyle or clinical factors....
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| Veröffentlicht in: | Cancer epidemiology 2014-10, Vol.38 (5), p.576-582 |
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| container_issue | 5 |
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| container_title | Cancer epidemiology |
| container_volume | 38 |
| creator | Neale, Rachel E Clark, Paul J Fawcett, Jonathan Fritschi, Lin Nagler, Belinda N Risch, Harvey A Walters, Rhiannon J Crawford, William J Webb, Penelope M Whiteman, David C Buchanan, Daniel D |
| description | Highlights • This is the largest study to examine the association between leukocyte DNA methylation and pancreatic cancer. • We found a significant association between Line-1 hypermethylation and risk of pancreatic cancer. • The association was largely unmodified by lifestyle or clinical factors. |
| doi_str_mv | 10.1016/j.canep.2014.08.006 |
| format | Article |
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Health state ; Biological and medical sciences ; Biomarkers ; Blood ; Cancer ; Case-Control Studies ; Consent ; Deoxyribonucleic acid ; DNA ; DNA - blood ; DNA Methylation ; Epidemiology ; Female ; Gene expression ; General aspects ; Health risk assessment ; Hematology, Oncology and Palliative Medicine ; Hospitals ; Humans ; Internal Medicine ; Leukocytes - metabolism ; Lifestyles ; LINE-1 ; Long Interspersed Nucleotide Elements - genetics ; Male ; Medical records ; Medical sciences ; Middle Aged ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - pathology ; Patients ; Polymerase Chain Reaction ; Population ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Repetitive DNA elements ; Risk ; Sat2 ; Smoking ; Surgery ; Tumors ; White blood cell DNA</subject><ispartof>Cancer epidemiology, 2014-10, Vol.38 (5), p.576-582</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-63f68b0ead448e9821915315465124511cd6866c65ce4bcbf1d203167873b3da3</citedby><cites>FETCH-LOGICAL-c575t-63f68b0ead448e9821915315465124511cd6866c65ce4bcbf1d203167873b3da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1614101940?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28855029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25201440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neale, Rachel E</creatorcontrib><creatorcontrib>Clark, Paul J</creatorcontrib><creatorcontrib>Fawcett, Jonathan</creatorcontrib><creatorcontrib>Fritschi, Lin</creatorcontrib><creatorcontrib>Nagler, Belinda N</creatorcontrib><creatorcontrib>Risch, Harvey A</creatorcontrib><creatorcontrib>Walters, Rhiannon J</creatorcontrib><creatorcontrib>Crawford, William J</creatorcontrib><creatorcontrib>Webb, Penelope M</creatorcontrib><creatorcontrib>Whiteman, David C</creatorcontrib><creatorcontrib>Buchanan, Daniel D</creatorcontrib><title>Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>Highlights • This is the largest study to examine the association between leukocyte DNA methylation and pancreatic cancer. • We found a significant association between Line-1 hypermethylation and risk of pancreatic cancer. • The association was largely unmodified by lifestyle or clinical factors.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alu</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Consent</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - blood</subject><subject>DNA Methylation</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene expression</subject><subject>General aspects</subject><subject>Health risk assessment</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Leukocytes - metabolism</subject><subject>Lifestyles</subject><subject>LINE-1</subject><subject>Long Interspersed Nucleotide Elements - genetics</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Patients</subject><subject>Polymerase Chain Reaction</subject><subject>Population</subject><subject>Public health. 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| ispartof | Cancer epidemiology, 2014-10, Vol.38 (5), p.576-582 |
| issn | 1877-7821 1877-783X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Age Aged Aged, 80 and over Alu Analysis. Health state Biological and medical sciences Biomarkers Blood Cancer Case-Control Studies Consent Deoxyribonucleic acid DNA DNA - blood DNA Methylation Epidemiology Female Gene expression General aspects Health risk assessment Hematology, Oncology and Palliative Medicine Hospitals Humans Internal Medicine Leukocytes - metabolism Lifestyles LINE-1 Long Interspersed Nucleotide Elements - genetics Male Medical records Medical sciences Middle Aged Pancreas Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Patients Polymerase Chain Reaction Population Public health. Hygiene Public health. Hygiene-occupational medicine Repetitive DNA elements Risk Sat2 Smoking Surgery Tumors White blood cell DNA |
| title | Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer |
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