Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer

Highlights • This is the largest study to examine the association between leukocyte DNA methylation and pancreatic cancer. • We found a significant association between Line-1 hypermethylation and risk of pancreatic cancer. • The association was largely unmodified by lifestyle or clinical factors....

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Veröffentlicht in:	Cancer epidemiology 2014-10, Vol.38 (5), p.576-582
Hauptverfasser:	Neale, Rachel E, Clark, Paul J, Fawcett, Jonathan, Fritschi, Lin, Nagler, Belinda N, Risch, Harvey A, Walters, Rhiannon J, Crawford, William J, Webb, Penelope M, Whiteman, David C, Buchanan, Daniel D
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Alu Analysis. Health state Biological and medical sciences Biomarkers Blood Cancer Case-Control Studies Consent Deoxyribonucleic acid DNA DNA - blood DNA Methylation Epidemiology Female Gene expression General aspects Health risk assessment Hematology, Oncology and Palliative Medicine Hospitals Humans Internal Medicine Leukocytes - metabolism Lifestyles LINE-1 Long Interspersed Nucleotide Elements - genetics Male Medical records Medical sciences Middle Aged Pancreas Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Patients Polymerase Chain Reaction Population Public health. Hygiene Public health. Hygiene-occupational medicine Repetitive DNA elements Risk Sat2 Smoking Surgery Tumors White blood cell DNA
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Zusammenfassung:	Highlights • This is the largest study to examine the association between leukocyte DNA methylation and pancreatic cancer. • We found a significant association between Line-1 hypermethylation and risk of pancreatic cancer. • The association was largely unmodified by lifestyle or clinical factors.
ISSN:	1877-7821 1877-783X
DOI:	10.1016/j.canep.2014.08.006