Kidney Transplant: Usefulness of Real-Time Elastography (RTE) in the Diagnosis of Graft Interstitial Fibrosis

Abstract The aim of this study is to evaluate the usefulness of real-time elastography (RTE) in the diagnosis of graft interstitial fibrosis. We prospectively enrolled 50 patients clinically suspected of graft fibrosis. RTE was performed with a broadband linear transducer using a dedicated ultrasoun...

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Veröffentlicht in:	Ultrasound in medicine & biology 2014-11, Vol.40 (11), p.2564-2572
Hauptverfasser:	Orlacchio, Antonio, MD, Chegai, Fabrizio, MD, Del Giudice, Costantino, MD, Anselmo, Alessandro, MD, Iaria, Giuseppe, MD, Palmieri, Giampiero, MD, Di Caprera, Elena, MD, Tosti, Daniela, MD, Costanzo, Elisa, MD, Tisone, Giuseppe, MD, Simonetti, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allograft biopsy Area Under Curve Biopsy - methods Elasticity imaging Elasticity Imaging Techniques - methods Female Fibrosis - diagnostic imaging Graft histology Humans Kidney - diagnostic imaging Kidney - pathology Kidney Diseases - diagnostic imaging Kidney Diseases - pathology Kidney Transplantation Male Observer Variation Postoperative Complications - diagnostic imaging Postoperative Complications - pathology Prospective Studies Radiology Reproducibility of Results ROC Curve Severity of Illness Index Ultrasound imaging
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Zusammenfassung:	Abstract The aim of this study is to evaluate the usefulness of real-time elastography (RTE) in the diagnosis of graft interstitial fibrosis. We prospectively enrolled 50 patients clinically suspected of graft fibrosis. RTE was performed with a broadband linear transducer using a dedicated ultrasound machine. Tissue mean elasticity (TME) was calculated by two blinded operators. All patients underwent biopsy after RTE. To determine cortical fibrosis Banff score was used. The receiver operating characteristic curves analysis was performed to evaluate the accuracy of TME to discriminate between patients with mild fibrosis (F1) versus patients with moderate to severe fibrosis (F2–F3). Inverse correlation between TME values and the degree of fibrosis has been shown ( p
ISSN:	0301-5629 1879-291X
DOI:	10.1016/j.ultrasmedbio.2014.06.002