Age-dependent effects of environmental enrichment on brain networks and spatial memory in Wistar rats

Highlights • EE improved the performance in young and aged rats. • The effect of EE on the distance travelled depending on the age of the animals. • EE had a different impact on the COx activity depending on the age. • PCA is a suitable statistical analysis to understand brain functional organizatio...

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Veröffentlicht in:	Neuroscience 2013-09, Vol.248, p.43-53
Hauptverfasser:	Sampedro-Piquero, P, Begega, A, Zancada-Menendez, C, Cuesta, M, Arias, J.L
Format:	Artikel
Sprache:	eng
Schlagworte:	ageing Animals Biological and medical sciences Brain - metabolism cytochrome c oxidase Electron Transport Complex IV - metabolism Environment environmental enrichment Fundamental and applied biological sciences. Psychology Male Nerve Net - metabolism Neurology principal component analysis Rats Rats, Wistar spatial learning Spatial Memory - physiology Vertebrates: nervous system and sense organs Wistar rat
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Beschreibung
Zusammenfassung:	Highlights • EE improved the performance in young and aged rats. • The effect of EE on the distance travelled depending on the age of the animals. • EE had a different impact on the COx activity depending on the age. • PCA is a suitable statistical analysis to understand brain functional organization. • The effect of EE was specific for the acquisition to the spatial task.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.06.003