Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration

Highlights ► We examined the mechanism of mitochondrial swelling and axonal degeneration. ► Energy failure occurred prior to mitochondrial swelling and axonal degeneration. ► Energy repletion prevented mitochondrial swelling and microtubule depolymerization. ► Perturbing microtubule dynamics enhance...

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Veröffentlicht in:	Neuroscience 2013-05, Vol.238, p.258-269
Hauptverfasser:	Park, J.Y, Jang, S.Y, Shin, Y.K, Koh, H, Suh, D.J, Shinji, T, Araki, T, Park, H.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon degeneration Axons - drug effects Axons - metabolism Axons - pathology Axotomy Biological and medical sciences energy Fundamental and applied biological sciences. Psychology Mice Mice, Inbred C57BL microtubule Microtubules - drug effects Microtubules - metabolism Microtubules - pathology mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial Swelling - drug effects Mitochondrial Swelling - physiology Neurology Paclitaxel - pharmacology Sciatic Nerve - injuries Sciatic Nerve - metabolism Sciatic Nerve - pathology Tubulin Modulators - pharmacology Vertebrates: nervous system and sense organs Vincristine - pharmacology Wallerian degeneration Wallerian Degeneration - metabolism Wallerian Degeneration - pathology
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Zusammenfassung:	Highlights ► We examined the mechanism of mitochondrial swelling and axonal degeneration. ► Energy failure occurred prior to mitochondrial swelling and axonal degeneration. ► Energy repletion prevented mitochondrial swelling and microtubule depolymerization. ► Perturbing microtubule dynamics enhanced axonal degeneration and mitochondrial swelling. ► Calcium was not related to mitochondrial swelling and microtubule depolymerization.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.02.033