Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury

Highlights ► G-CSFR was expressed on microglia which was co-labeled with microglia marker CD11b. ► IBA1+ cells in contralateral side were significantly less than that in injured side. ► M2 macrophage markers increased and M1 macrophage markers decreased after G-CSF. ► NFκB increased in BV2 after tre...

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Veröffentlicht in:	Neuroscience 2013-05, Vol.238, p.1-10
Hauptverfasser:	Guo, Y, Zhang, H, Yang, J, Liu, S, Bing, L, Gao, J, Hao, A
Format:	Artikel
Sprache:	eng
Schlagworte:	alternatively activated microglia Animals Biological and medical sciences classically activated microglia Female Fundamental and applied biological sciences. Psychology granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte Colony-Stimulating Factor - therapeutic use Mice microglia Microglia - drug effects Microglia - pathology Neurology Neurons - drug effects Neurons - physiology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Recovery of Function - drug effects Recovery of Function - physiology Spinal Cord - drug effects Spinal Cord - pathology Spinal Cord - physiopathology spinal cord hemisection Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► G-CSFR was expressed on microglia which was co-labeled with microglia marker CD11b. ► IBA1+ cells in contralateral side were significantly less than that in injured side. ► M2 macrophage markers increased and M1 macrophage markers decreased after G-CSF. ► NFκB increased in BV2 after treatment with injured spinal cord supernatant.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.01.047