GABAB receptors as a common target for hypothermia and spike and wave seizures: Intersecting mechanisms of thermoregulation and absence epilepsy

Highlights ► PTZ and GHB induced both absence seizures and mild hypothermia. ► Drug-free deep cooling induced frequent SWD and accompanied behavioral correlates. ► A selective GABAB antagonists prevented both the hypothermia and SWD. ► GABAB receptors connect the thermoregulation and absence epilept...

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Veröffentlicht in:	Neuroscience 2013-05, Vol.238, p.39-58
Hauptverfasser:	Ostojić, Z.S, Ilić, T.V, Vesković, S.M, Andjus, P.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Benzoates - pharmacology Benzoates - therapeutic use Biological and medical sciences Body Temperature Regulation - drug effects Body Temperature Regulation - physiology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Diazepam - pharmacology Diazepam - therapeutic use Epilepsy, Absence - chemically induced Epilepsy, Absence - drug therapy Epilepsy, Absence - metabolism Epilepsy, Absence - physiopathology Fundamental and applied biological sciences. Psychology GABAB GHB Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hypothalamus hypothermia Hypothermia - chemically induced Hypothermia - metabolism Hypothermia - physiopathology Male Medical sciences Nervous system (semeiology, syndromes) Neurology Organophosphorus Compounds - pharmacology Organophosphorus Compounds - therapeutic use Pentylenetetrazole PTZ Rats Rats, Wistar Receptors, GABA-B - metabolism Seizures - chemically induced Seizures - drug therapy Seizures - metabolism Seizures - physiopathology Sodium Oxybate SWD Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► PTZ and GHB induced both absence seizures and mild hypothermia. ► Drug-free deep cooling induced frequent SWD and accompanied behavioral correlates. ► A selective GABAB antagonists prevented both the hypothermia and SWD. ► GABAB receptors connect the thermoregulation and absence epileptogenecity. ► The role of the preoptic hypothalamic nuclei in absence epilepsy has to be reconsidered.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.01.072