Osteopontin inhibits osmotic swelling of retinal glial (Müller) cells by inducing release of VEGF

Highlights • Osteopontin inhibits osmotic swelling of retinal glial cells. • Osteopontin does not inhibit osmotic swelling of bipolar cells. • Osteopontin induces glial release of VEGF and adenosine. • Retinal glial cells are immunolabeled for osteopontin. • Inhibition of cytotoxic glial swelling ma...

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Veröffentlicht in:	Neuroscience 2013-08, Vol.246, p.59-72
Hauptverfasser:	Wahl, V, Vogler, S, Grosche, A, Pannicke, T, Ueffing, M, Wiedemann, P, Reichenbach, A, Hauck, S.M, Bringmann, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Ependymoglial Cells - drug effects Ependymoglial Cells - secretion Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology glia ischemia Neuroglia - drug effects Neuroglia - secretion Neurology Organ Culture Techniques Osmosis - drug effects Osmosis - physiology Osmotic Pressure - drug effects Osmotic Pressure - physiology osmotic swelling osteopontin Osteopontin - pharmacology Rats Rats, Long-Evans retina Retina - drug effects Retina - secretion Vascular Endothelial Growth Factor A - secretion VEGF Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Osteopontin inhibits osmotic swelling of retinal glial cells. • Osteopontin does not inhibit osmotic swelling of bipolar cells. • Osteopontin induces glial release of VEGF and adenosine. • Retinal glial cells are immunolabeled for osteopontin. • Inhibition of cytotoxic glial swelling may be neuroprotective.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.04.045