Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis

Highlights • We found that tropisetron has considerable immunoregulatory functions in MOG-EAE. • Effects of tropisetron seem to be receptor dependent and receptor independent. • Tropisetron and granisetron attenuated the clinical and histological signs of EAE. • Tropisetron and also granisetron redu...

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Veröffentlicht in:	Neuroscience 2013-09, Vol.248, p.299-306
Hauptverfasser:	Aminian, A, Noorbakhsh, F, Ghazi-Khansari, M, Kafami, L, Javadi, S, Hassanzadeh, G, Rahimian, R, Dehpour, A.R, Mehr, S.E
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT3 receptor Animals Biguanides - administration & dosage Biguanides - pharmacology Biological and medical sciences Cell Proliferation - drug effects Cerebrospinal fluid. Meninges. Spinal cord Demyelinating Diseases - drug therapy Disease Models, Animal Dose-Response Relationship, Drug Drug Therapy, Combination Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism experimental autoimmune encephalomyelitis Fundamental and applied biological sciences. Psychology Granisetron - administration & dosage Granisetron - pharmacology Indoles - administration & dosage Indoles - pharmacology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Medical sciences Mice Mice, Inbred C57BL multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis - etiology Multiple Sclerosis - pathology Nervous system (semeiology, syndromes) Neurology Receptors, Serotonin, 5-HT3 - drug effects Serotonin 5-HT3 Receptor Agonists - administration & dosage Serotonin 5-HT3 Receptor Agonists - pharmacology Serotonin 5-HT3 Receptor Antagonists - administration & dosage Serotonin 5-HT3 Receptor Antagonists - pharmacology Spinal Cord - drug effects Spinal Cord - pathology Spleen - cytology Treatment Outcome tropisetron Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • We found that tropisetron has considerable immunoregulatory functions in MOG-EAE. • Effects of tropisetron seem to be receptor dependent and receptor independent. • Tropisetron and granisetron attenuated the clinical and histological signs of EAE. • Tropisetron and also granisetron reduced proliferation of T cells. • Tropisetron and also granisetron suppressed production of inflammatory cytokines.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.06.009