Th17 cells in inflammation and autoimmunity
Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL...
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| Veröffentlicht in: | Autoimmunity reviews 2014-12, Vol.13 (12), p.1174-1181 |
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| container_title | Autoimmunity reviews |
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| creator | Singh, Ram Pyare Hasan, Sascha Sharma, Sherven Nagra, Saranpreet Yamaguchi, Dean T Wong, David T.W Hahn, Bevra H Hossain, Awlad |
| description | Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention. |
| doi_str_mv | 10.1016/j.autrev.2014.08.019 |
| format | Article |
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Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.</description><identifier>ISSN: 1568-9972</identifier><identifier>EISSN: 1873-0183</identifier><identifier>DOI: 10.1016/j.autrev.2014.08.019</identifier><identifier>PMID: 25151974</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Allergy and Immunology ; Animals ; Autoimmune Diseases - immunology ; Autoimmunity ; Gonadal Steroid Hormones - immunology ; Humans ; Inflammation - immunology ; Interleukin-17 - immunology ; Mesenchymal Stromal Cells - immunology ; Th17 Cells - immunology</subject><ispartof>Autoimmunity reviews, 2014-12, Vol.13 (12), p.1174-1181</ispartof><rights>Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. 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Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmunity</subject><subject>Gonadal Steroid Hormones - immunology</subject><subject>Humans</subject><subject>Inflammation - immunology</subject><subject>Interleukin-17 - immunology</subject><subject>Mesenchymal Stromal Cells - immunology</subject><subject>Th17 Cells - immunology</subject><issn>1568-9972</issn><issn>1873-0183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLwzAUx4Mobk6_gcgeBWnNyaVJXgQZ3mDgg_M5pF2Kqb3MpB3s25vSKRw4h8P_fy4_hK4Bp4Ahu69SM_Te7lOCgaVYphjUCZqDFDTBIOlprHkmE6UEmaGLECocbYqoczQjHDgowebobvMFYlnYug5L18Yoa9M0pndduzTtdhl3dK5phtb1h0t0Vpo62KtjXqDP56fN6jVZv7-8rR7XScEy6BNaUmFVaRVnWMoCQFDCCS8N49LkhOYiZ4rlUhlDqQCqYl9hwiXPBKFA6ALdTnN3vvsZbOh148J4omltNwQNGeWYEMYhStkkLXwXgrel3nnXGH_QgPWISVd6wqRHTBpLHTFF281xw5A3dvtv-uMSBQ-TwMY_9856XdSudYWpv-3BhqobfBsRaNCBaKw_RtIjaGAjZErpL-f1dyY</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Singh, Ram Pyare</creator><creator>Hasan, Sascha</creator><creator>Sharma, Sherven</creator><creator>Nagra, Saranpreet</creator><creator>Yamaguchi, Dean T</creator><creator>Wong, David T.W</creator><creator>Hahn, Bevra H</creator><creator>Hossain, Awlad</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20141201</creationdate><title>Th17 cells in inflammation and autoimmunity</title><author>Singh, Ram Pyare ; Hasan, Sascha ; Sharma, Sherven ; Nagra, Saranpreet ; Yamaguchi, Dean T ; Wong, David T.W ; Hahn, Bevra H ; Hossain, Awlad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-3f37e9fe954088c11732525fa458ab23b7b494b89aa3371394589025856723123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmunity</topic><topic>Gonadal Steroid Hormones - immunology</topic><topic>Humans</topic><topic>Inflammation - immunology</topic><topic>Interleukin-17 - immunology</topic><topic>Mesenchymal Stromal Cells - immunology</topic><topic>Th17 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Ram Pyare</creatorcontrib><creatorcontrib>Hasan, Sascha</creatorcontrib><creatorcontrib>Sharma, Sherven</creatorcontrib><creatorcontrib>Nagra, Saranpreet</creatorcontrib><creatorcontrib>Yamaguchi, Dean T</creatorcontrib><creatorcontrib>Wong, David T.W</creatorcontrib><creatorcontrib>Hahn, Bevra H</creatorcontrib><creatorcontrib>Hossain, Awlad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Autoimmunity reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Ram Pyare</au><au>Hasan, Sascha</au><au>Sharma, Sherven</au><au>Nagra, Saranpreet</au><au>Yamaguchi, Dean T</au><au>Wong, David T.W</au><au>Hahn, Bevra H</au><au>Hossain, Awlad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Th17 cells in inflammation and autoimmunity</atitle><jtitle>Autoimmunity reviews</jtitle><addtitle>Autoimmun Rev</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>13</volume><issue>12</issue><spage>1174</spage><epage>1181</epage><pages>1174-1181</pages><issn>1568-9972</issn><eissn>1873-0183</eissn><abstract>Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.</abstract><cop>Netherlands</cop><pmid>25151974</pmid><doi>10.1016/j.autrev.2014.08.019</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1568-9972 |
| ispartof | Autoimmunity reviews, 2014-12, Vol.13 (12), p.1174-1181 |
| issn | 1568-9972 1873-0183 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Allergy and Immunology Animals Autoimmune Diseases - immunology Autoimmunity Gonadal Steroid Hormones - immunology Humans Inflammation - immunology Interleukin-17 - immunology Mesenchymal Stromal Cells - immunology Th17 Cells - immunology |
| title | Th17 cells in inflammation and autoimmunity |
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