Th17 cells in inflammation and autoimmunity

Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL...

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Veröffentlicht in:	Autoimmunity reviews 2014-12, Vol.13 (12), p.1174-1181
Hauptverfasser:	Singh, Ram Pyare, Hasan, Sascha, Sharma, Sherven, Nagra, Saranpreet, Yamaguchi, Dean T, Wong, David T.W, Hahn, Bevra H, Hossain, Awlad
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autoimmune Diseases - immunology Autoimmunity Gonadal Steroid Hormones - immunology Humans Inflammation - immunology Interleukin-17 - immunology Mesenchymal Stromal Cells - immunology Th17 Cells - immunology
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Zusammenfassung:	Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.
ISSN:	1568-9972 1873-0183
DOI:	10.1016/j.autrev.2014.08.019