Efficacy of a formalin-inactivated vaccine against Streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization

Efficacy of a formalin-inactivated vaccine against Streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization

Highlights • Proposed vaccine induces the upregulation of immune-related genes. • Vaccinated fish showed significant increase of phagocytic activity. • Groupers vaccinated using the tested vaccine had increased serum agglutination titers. • Proposed vaccine provides protective efficacy against S. in...

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Veröffentlicht in:Vaccine 2014-12, Vol.32 (51), p.7014-7020
Hauptverfasser: Huang, Hsing-Yen, Chen, Yan-Chun, Wang, Pei-Chi, Tsai, Ming-An, Yeh, Shih-Chun, Liang, Hong-Jen, Chen, Shih-Chu
Format: Artikel
Sprache:eng
Schlagworte:
Agglutination Tests
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Applied microbiology
Bacteriology
Bass
Biological and medical sciences
Epinephelus coioides
Fish Diseases - prevention & control
Fundamental and applied biological sciences. Psychology
Immunization - methods
Immunoglobulin M - blood
Injections, Intraperitoneal
Interleukin-1beta - analysis
Leukocytes, Mononuclear - immunology
Marine
Microbiology
Miscellaneous
Phagocytosis
Streptococcal Infections - prevention & control
Streptococcal Infections - veterinary
Streptococcal Vaccines - administration & dosage
Streptococcal Vaccines - immunology
Streptococcus - immunology
Streptococcus - isolation & purification
Streptococcus iniae
Survival Analysis
Tumor Necrosis Factor-alpha - analysis
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
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Beschreibung
Zusammenfassung:Highlights • Proposed vaccine induces the upregulation of immune-related genes. • Vaccinated fish showed significant increase of phagocytic activity. • Groupers vaccinated using the tested vaccine had increased serum agglutination titers. • Proposed vaccine provides protective efficacy against S. iniae. • Proposed vaccine provides safe and long-lasting protection in farmed groupers.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.08.039