Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study
Highlights • Caffeine enhances task-related BOLD activation and functional connectivity in the elderly. • Task-related BOLD activation enhancement predominates in the striatum. • Functional connectivity increases in working memory-related networks by 8.2%. • Caffeine reduces baseline perfusion by 23...
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| Veröffentlicht in: | Neuroscience 2013-10, Vol.250, p.364-371 |
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| creator | Haller, S Rodriguez, C Moser, D Toma, S Hofmeister, J Sinanaj, I Van De Ville, D Giannakopoulos, P Lovblad, K.-O |
| description | Highlights • Caffeine enhances task-related BOLD activation and functional connectivity in the elderly. • Task-related BOLD activation enhancement predominates in the striatum. • Functional connectivity increases in working memory-related networks by 8.2%. • Caffeine reduces baseline perfusion by 23% (global vasoconstriction). |
| doi_str_mv | 10.1016/j.neuroscience.2013.07.021 |
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Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term - drug effects</subject><subject>Middle Aged</subject><subject>Neural Pathways - drug effects</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Oxygen - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Principal Component Analysis</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychopharmacology</subject><subject>Spin Labels</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkluP1CAUgInRuOvoXzDExMSXjsBpS2cfTMZdL5uM2cTLM2HgoMy2dBbaNf0r_lqpM17ii_IChO-cA3yHkCecLTnj9fPdMuAY-2Q8BoNLwTgsmVwywe-QU95IKGRVlnfJKQNWF2UlxAl5kNKO5VGVcJ-cCGhkDQJOybe1GQekRjuHPiDVtvPBpyHqwfeB-m6vzUDz6msfr334TDvs-jgVEVs9oKXbqH2gmfG3hwgdLHVjMPNGt9T0IeB86oeJZnL4ghRbi7GdzuiavrzaXPwI2WN0Y5oTvHt_SdMw2ukhued0m_DRcV6QT69ffTx_W2yu3lyerzeFqSo2FABWNOXKMlkh1NBY60rBZeWAwaq0TOuqRslW6ADQbblstGgcB1OvpISGwYI8O-Tdx_5mxDSozieDbasD9mNSvIYq_21O9m-0BC5WZV2LjJ4dUJNNpYhO7aPvdJwUZ2rWqHbqT41q1qiYVHOpBXl8rDNuO7S_Qn96y8DTI6CT0a2LOhiffnNSyuy6ztzFgcP8gbceozqWsz5mLcr2_v_u8-KvNKbNbZIrX-OEadePMcvO71dJKKY-zI039x0HxuqsAb4D_9XYWQ</recordid><startdate>20131010</startdate><enddate>20131010</enddate><creator>Haller, S</creator><creator>Rodriguez, C</creator><creator>Moser, D</creator><creator>Toma, S</creator><creator>Hofmeister, J</creator><creator>Sinanaj, I</creator><creator>Van De Ville, D</creator><creator>Giannakopoulos, P</creator><creator>Lovblad, K.-O</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20131010</creationdate><title>Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study</title><author>Haller, S ; Rodriguez, C ; Moser, D ; Toma, S ; Hofmeister, J ; Sinanaj, I ; Van De Ville, D ; Giannakopoulos, P ; Lovblad, K.-O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-33d2849d075e3638ddf42175f30394d0aa56e709ef33efb178a28f13c69773803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>Biological and medical sciences</topic><topic>BOLD</topic><topic>Brain - drug effects</topic><topic>caffeine</topic><topic>Caffeine - pharmacology</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>cognition</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>fMRI</topic><topic>Fundamental and applied biological sciences. 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| subjects | Aged Aged, 80 and over aging Biological and medical sciences BOLD Brain - drug effects caffeine Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Cerebrovascular Circulation - drug effects cognition Cross-Over Studies Double-Blind Method Female fMRI Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Linear Models Magnetic Resonance Imaging Male Medical sciences Memory, Short-Term - drug effects Middle Aged Neural Pathways - drug effects Neurology Neuropharmacology Oxygen - blood Pharmacology. Drug treatments Principal Component Analysis Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopharmacology Spin Labels Vertebrates: nervous system and sense organs |
| title | Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study |
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