Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study

Highlights • Caffeine enhances task-related BOLD activation and functional connectivity in the elderly. • Task-related BOLD activation enhancement predominates in the striatum. • Functional connectivity increases in working memory-related networks by 8.2%. • Caffeine reduces baseline perfusion by 23...

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Veröffentlicht in:	Neuroscience 2013-10, Vol.250, p.364-371
Hauptverfasser:	Haller, S, Rodriguez, C, Moser, D, Toma, S, Hofmeister, J, Sinanaj, I, Van De Ville, D, Giannakopoulos, P, Lovblad, K.-O
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over aging Biological and medical sciences BOLD Brain - drug effects caffeine Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Cerebrovascular Circulation - drug effects cognition Cross-Over Studies Double-Blind Method Female fMRI Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Linear Models Magnetic Resonance Imaging Male Medical sciences Memory, Short-Term - drug effects Middle Aged Neural Pathways - drug effects Neurology Neuropharmacology Oxygen - blood Pharmacology. Drug treatments Principal Component Analysis Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopharmacology Spin Labels Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Caffeine enhances task-related BOLD activation and functional connectivity in the elderly. • Task-related BOLD activation enhancement predominates in the striatum. • Functional connectivity increases in working memory-related networks by 8.2%. • Caffeine reduces baseline perfusion by 23% (global vasoconstriction).
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.07.021