Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats

Highlights • H2 S has a hyperalgesic effect in non-diabetic and diabetic rats. • Cystathionine β-synthase and cystathionine γ-lyase participate H2 S-induced hyperalgesia. • Cystathionine β-synthase and cystathionine γ-lyase contributes streptozotocin-induced allodynia. • H2 S concentration decreases...

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Veröffentlicht in:	Neuroscience 2013-10, Vol.250, p.786-797
Hauptverfasser:	Velasco-Xolalpa, M.E, Barragán-Iglesias, P, Roa-Coria, J.E, Godínez-Chaparro, B, Flores-Murrieta, F.J, Torres-López, J.E, Araiza-Saldaña, C.I, Navarrete, A, Rocha-González, H.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alkynes - pharmacology Animals Biological and medical sciences Blood Glucose - metabolism Cystathionine gamma-Lyase - metabolism Cysteine - antagonists & inhibitors Cysteine - pharmacology Data Interpretation, Statistical Diabetes Mellitus, Experimental - complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female formalin test Fundamental and applied biological sciences. Psychology Glycine - analogs & derivatives Glycine - pharmacology hydrogen sulfide Hydrogen Sulfide - metabolism Hydrogen Sulfide - pharmacology Hydroxylamine - pharmacology Hyperalgesia - chemically induced Hyperalgesia - psychology inflammatory pain Medical sciences Neural Pathways - drug effects Neurology neuropathy Nociception - physiology Pain - psychology Pain Measurement Physical Stimulation Rats Rats, Wistar streptozotocin-induced diabetes tactile allodynia Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • H2 S has a hyperalgesic effect in non-diabetic and diabetic rats. • Cystathionine β-synthase and cystathionine γ-lyase participate H2 S-induced hyperalgesia. • Cystathionine β-synthase and cystathionine γ-lyase contributes streptozotocin-induced allodynia. • H2 S concentration decreases with experimental diabetes development along nociceptive pathway. • Diabetic rats are more sensitive to H2 S than non-diabetic rats.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.06.053