BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration

In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR...

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Veröffentlicht in:	Neuroreport 2014-05, Vol.25 (8), p.549-555
Hauptverfasser:	Saglam, Aybike, Kim, Sukbum, Ahn, Kwangwook, Oh, Insuk, Lee, Kwan-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - physiology Biological and medical sciences Bone Morphogenetic Protein 2 - pharmacology Brain - cytology Cell Proliferation - drug effects Cells, Cultured Coculture Techniques Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Mice Nerve Degeneration - prevention & control Neurites - drug effects Neuroblastoma - pathology Neurons - drug effects Neurons - physiology Neuroprotective Agents - pharmacology PC12 Cells Rats Signal Transduction - drug effects Tubulin - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/WNR.0000000000000130