Regulation of Pseudomonas aeruginosa virulence factors by two novel RNA thermometers

In a number of bacterial pathogens, the production of virulence factors is induced at 37 °C; this effect is often regulated by mRNA structures formed in the 5′ untranslated region (UTR) that block translation initiation of genes at environmental temperatures. At 37 °C, the RNA structures become unst...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (43), p.15562-15567
Hauptverfasser:	Grosso-Becerra, María Victoria, Croda-García, Gerardo, Merino, Enrique, Servín-González, Luis, Mojica-Espinosa, Raúl, Soberón-Chávez, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Bacterial Proteins - metabolism Base Sequence Binding sites Biological Sciences Correlation analysis Gene expression regulation Gene Expression Regulation, Bacterial Genes Homoserine - analogs & derivatives Homoserine - metabolism Intracellular Space - metabolism Lactones - metabolism Molecular Sequence Data Operon - genetics Operons Pathogens Plasmids Polymerase chain reaction Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - growth & development Pseudomonas aeruginosa - pathogenicity Real-Time Polymerase Chain Reaction Regulatory Sequences, Nucleic Acid - genetics Ribonucleic acid RNA RNA, Bacterial - metabolism Temperature Thermometers Thermoregulation Transcription, Genetic Untranslated regions Virulence factors Virulence Factors - metabolism
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