Aberrant proteomic expression of NSRP70 and its clinical implications and connection to the transcriptional level in adult acute leukemia

Highlights • Abe-NSRP70 is a novel ALL surrogate marker. • Abe-hi-NSRP70 relates to adverse genetic abnormalities in AML. • 3 Abe-SFPs (NSRP70, SRSF1, and HNRNPA1) are putative diagnostic markers of adult ALL. • Incidences of 3 Abe-SFPs are high in ALL compared with AML. • 3 Abe-SFPs can be formed w...

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Veröffentlicht in:	Leukemia research 2014-10, Vol.38 (10), p.1252-1259
Hauptverfasser:	Choi, Dan-Bee, Park, Moo-Rim, Kim, Hak-Ryul, Jun, Chang-Duk, Kim, Hyeoung-Joon, Shim, Hyeok, Kim, Young-Dae, Choi, Chan, Choi, Keum-Ha, Yun, Ki Jung, Chae, Soo-Cheon, Park, Raekil, Choe, Seong-Kyu, Lee, Young-Jin, Park, Do-Sim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute leukemia Adult Aged Aged, 80 and over Alternative Splicing Biomarkers, Tumor - analysis Female Fluorescent Antibody Technique Hematology, Oncology and Palliative Medicine HNRNPA1 Humans Immunoblotting Male Middle Aged NSRP70 Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Proteomics Splicing factor protein SRSF1 Transcription, Genetic Young Adult
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Zusammenfassung:	Highlights • Abe-NSRP70 is a novel ALL surrogate marker. • Abe-hi-NSRP70 relates to adverse genetic abnormalities in AML. • 3 Abe-SFPs (NSRP70, SRSF1, and HNRNPA1) are putative diagnostic markers of adult ALL. • Incidences of 3 Abe-SFPs are high in ALL compared with AML. • 3 Abe-SFPs can be formed without coding mutations or mRNA level elevation in AL.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2014.08.001