RNA activation: Promise as a new weapon against cancer

Highlight • RNAa is a novel mechanism in which short RNA duplexes enable gene activation that lasts up to 2 weeks. • RNAa, named in contrast to RNAi, has emerged as a new member of the non-coding RNA kingdom. • RNAa provides a novel mechanism for the study of gene function and regulation. • RNAa hol...

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Veröffentlicht in:	Cancer letters 2014-12, Vol.355 (1), p.18-24
Hauptverfasser:	Zheng, Lin, Wang, Lu, Gan, Jinfeng, Zhang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding Sites Biology Bladder cancer Breast cancer Enzymes Epigenetic Epigenetics Gene expression Gene Expression Regulation, Neoplastic Gene function Genetic engineering Genetic Therapy - methods Hematology, Oncology and Palliative Medicine Humans Liver cancer Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Non-coding RNA Proteins RNA - genetics RNA - metabolism RNA - therapeutic use RNA-based therapeutics Small RNA-mediated transcriptional activation Studies Transcription, Genetic Transcriptional Activation Tumor suppressor
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Zusammenfassung:	Highlight • RNAa is a novel mechanism in which short RNA duplexes enable gene activation that lasts up to 2 weeks. • RNAa, named in contrast to RNAi, has emerged as a new member of the non-coding RNA kingdom. • RNAa provides a novel mechanism for the study of gene function and regulation. • RNAa holds exciting potential for clinical translation to therapeutic modality against cancers.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.09.004