Replicative study of GWAS TP63C/T , TERTC/T , and SLC14A1C/T with susceptibility to bladder cancer in North Indians

Abstract Objective Genome-wide association studies have confirmed association of TP63C/T rs710521, TERTC/T rs2736098, and SLC14A1C/T rs17674580 gene variants with susceptibility to bladder cancer (BC) in European and White population. However, the risk conferred for BC for above gene variants in North Indians is unknown. We therefore, studied the association of TP63C/T , TERTC/T , and SLC14A1C/T single nucleotide polymorphisms (SNPs) with a risk of BC susceptibility in North Indian cohort. Material and methods In histologically confirmed 225 BC cases and 240 healthy controls, 3 SNPs were genotyped by real-time polymerase chain reaction. To evaluate the SNP effects on BC susceptibility, odds ratio (OR) and CI 95% were calculated. Results In case of TP63C/T , the variant genotype (TT) showed significant reduced risk for BC ( P = 0.045, OR = 0.53). Combining heterozygous and variant genotypes also demonstrated reduced risk for BC ( P < 0.001, OR = 0.54). In case of TERTC/T , heterozygous genotype (CT) as well as variant genotype (TT) showed significant risk for BC susceptibility ( P = 0.031, OR = 1.77 and P = 0.004, OR = 2.78, respectively) along with T allelic level ( P