Choline phosphate functionalized surface: protein-resistant but cell-adhesive zwitterionic surface potential for tissue engineering

Choline phosphate functionalized surface: protein-resistant but cell-adhesive zwitterionic surface potential for tissue engineering

A choline phosphate (CP) modified surface is designed to resist protein adsorption due to its zwitterionic properties and simultaneously promote cell adhesion though its universal interaction with phosphate choline (PC) headgroups of the cell membrane. This work provides a new approach to obtain a c...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (3), p.487-490
Hauptverfasser: Chen, Xingyu, Chen, Tianchan, Lin, Zaifu, Li, Xian'e, Wu, Wei, Li, Jianshu
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Transport Systems, Neutral - chemistry
Cell Adhesion
Cell Membrane - chemistry
Hydrophobic and Hydrophilic Interactions
Microscopy, Confocal
Phosphorylcholine - chemistry
Surface Properties
Tissue Engineering
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container_end_page 490
container_issue 3
container_start_page 487
container_title Chemical communications (Cambridge, England)
container_volume 51
creator Chen, Xingyu
Chen, Tianchan
Lin, Zaifu
Li, Xian'e
Wu, Wei
Li, Jianshu
description A choline phosphate (CP) modified surface is designed to resist protein adsorption due to its zwitterionic properties and simultaneously promote cell adhesion though its universal interaction with phosphate choline (PC) headgroups of the cell membrane. This work provides a new approach to obtain a cell-adhesive surface with a non-biofouling 'background', which has a potential for tissue engineering.
doi_str_mv 10.1039/c4cc08681c
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Amino Acid Transport Systems, Neutral - chemistry
Cell Adhesion
Cell Membrane - chemistry
Hydrophobic and Hydrophilic Interactions
Microscopy, Confocal
Phosphorylcholine - chemistry
Surface Properties
Tissue Engineering
title Choline phosphate functionalized surface: protein-resistant but cell-adhesive zwitterionic surface potential for tissue engineering
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