Choline phosphate functionalized surface: protein-resistant but cell-adhesive zwitterionic surface potential for tissue engineering

A choline phosphate (CP) modified surface is designed to resist protein adsorption due to its zwitterionic properties and simultaneously promote cell adhesion though its universal interaction with phosphate choline (PC) headgroups of the cell membrane. This work provides a new approach to obtain a c...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (3), p.487-490
Hauptverfasser:	Chen, Xingyu, Chen, Tianchan, Lin, Zaifu, Li, Xian'e, Wu, Wei, Li, Jianshu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems, Neutral - chemistry Cell Adhesion Cell Membrane - chemistry Hydrophobic and Hydrophilic Interactions Microscopy, Confocal Phosphorylcholine - chemistry Surface Properties Tissue Engineering
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Beschreibung
Zusammenfassung:	A choline phosphate (CP) modified surface is designed to resist protein adsorption due to its zwitterionic properties and simultaneously promote cell adhesion though its universal interaction with phosphate choline (PC) headgroups of the cell membrane. This work provides a new approach to obtain a cell-adhesive surface with a non-biofouling 'background', which has a potential for tissue engineering.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c4cc08681c