T3 supplementation affects ventilatory timing & glucose levels in type 2 diabetes mellitus model

Highlights • Streptozotocin (STZ) and nicotinamide (N) increased blood glucose, but did not affect ventilation. • Treatment of STZ/N rats with T3 altered T I and decreased blood glucose levels. • In STZ/N rats treated with T3 T I and blood glucose levels were highly correlated.

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Bibliographische Detailangaben
Veröffentlicht in:	Respiratory physiology & neurobiology 2015-01, Vol.205, p.92-98
Hauptverfasser:	Bollinger, Stephen S, Weltman, Nathen Y, Gerdes, A. Martin, Schlenker, Evelyn H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood glucose Blood Glucose - drug effects Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Female Medical Education Pulmonary Ventilation - drug effects Pulmonary/Respiratory Rats Rats, Sprague-Dawley Triiodothyronine Triiodothyronine - pharmacology Type 2 diabetes mellitus Ventilation
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Beschreibung
Zusammenfassung:	Highlights • Streptozotocin (STZ) and nicotinamide (N) increased blood glucose, but did not affect ventilation. • Treatment of STZ/N rats with T3 altered T I and decreased blood glucose levels. • In STZ/N rats treated with T3 T I and blood glucose levels were highly correlated.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2014.10.020